The use of long-term bone marrow cultures (LTBMC) to detect hematotoxic side effects of purging methods.
نویسندگان
چکیده
With a view to the establishment of purging methods it is necessary to investigate complete-remission bone marrow as the real target of purging, rather than bone marrow from healthy donors. The results of LTBMC are superior to those of GM-CFC where the hematopoietic recovery of bone marrow is concerned. One-stage LTBMC after bone marrow manipulations may reflect mixed hematopoietic/stromal effects. The use of two-stage LTBMC allows the evaluation of the stem cell recovery without the possible influence of a damaged microenvironment.
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عنوان ژورنال:
- Haematology and blood transfusion
دوره 32 شماره
صفحات -
تاریخ انتشار 1989